Computational Fluid Dynamics (CFD) using the commercial CFD package CFDesign has been performed at NASA Jet Propulsion Laboratory (JPL) California Institute of Technology (Caltech) in support of the Phaeton Early Career Hire Program’s Optical Payload for Lasercomm Science (OPALS) mission. The OPALS project is one which involves an International Space Station payload that will be using forced convection cooling in a hermetically sealed enclosure at 1 atm of air to cool “off-the-shelf” vendor electronics. The CFD analysis was used to characterize the thermal and fluid flow environment within a complicated labyrinth of electronics boards, fans, instrumentation, harnessing, ductwork and heat exchanger fins. The paradigm of iteratively using CAD/CAE tools and CFD was followed in order to determine the optimum flow geometry and heat sink configuration to yield operational convective film coefficients and temperature survivability limits for the electronics payload. Results from this current CFD analysis and correlation of the CFD model against thermal test data will be presented. Lessons learned and coupled thermal / flow modeling strategies will be shared in this paper.